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Separation type: Bridge Ion Separation Technology, or BIST™ by SIELC Technologies
Bivalirudin is a short, 21-amino-acid peptide. It has 2 basic and 6 acidic groups. It is a naturally-occurring anticoagulant. Asp9-bivalirudin is a process impurity and can be a result of the degradation of the drug bivalirudin. SIELC’s new BIST™ mode can retain and separate Bivalirudin and its degredant with a TMDAP phosphate buffer, and the respective retention times can be controlled by altering the pH of the buffer.
|Column||BIST™ A+, 2.1×100 mm, 3µm, 100A|
|Mobile Phase||MeCN – 30%|
|Buffer||TMDAP phosphate – 10 mM pH 5.0, pH 6.0|
|Flow Rate||0.2 mL/min|
|Detection||UV 275 nm|
|Class of Compounds||Drugs, Anticoagulant|
|Analyzing Compounds||Bivalirudin and Asp9 – bivalirudin is a process impurity|